(disclaimer: I haven't done this to a 0300)
In short, it's possible.
There's an easily removable torsion bar inside the scale. Removing it will disable the spring action. Unfortunately the torsion bar also acts to retain the blade when closed. Manual-action knives have a hole in the blade that interlocks with the small ball-bearing on the inside of the lock. To restore proper blade-retention, you need to precisely drill a hole for the detent-ball. Locating the hole isn't too difficult, the ball wears a faint path in the blade. Drilling hardened blade steel requires a specialized bit. Solid-carbide, straight flute bits work well, but are expensive and brittle.
There are downsides to this. First, it is a permanent alteration to the blade. Don't screw up. Second, the flipper was never designed for manual action, and may not provide enough leverage for good flipping action. Third, if you want to go back to AO, there will be extra resistance to opening. Possibly making the thumbstuds very difficult to use.