I use it on all my CRKs. Not sure if it’s needed or not, but the extra security is nice. Just a little drop on every screw. CRK includes it, so I’m going to use it. Never had a problem disassembling a CRK with the Loctite on the threads and I’ve never had a screw back out.
I think, and this is just me thinking, is that CRK almost does too good a job with their fasteners. I’ve had other knives where the screws don’t want to go in while with my CRKs the screws seat smoothly. I believe that this means that the tolerances are tight enough that there is no grinding or deformation of metal with the screws that would keep them in place. Rolex watches have a similar issue where the screws holding the bracelet links together need loctite on them otherwise they’ll back out over time. IMO I’d rather have something precision made that can be disassembled/assembled repeatedly with the help of a little loctite vs screws that will deform or change/ruin the threading over time.