'Best way' depends entirely on your own skills and preferences. The most skilled sharpeners can put hair-popping edges on knives using almost anything that's available to them. In their own shop, where all of their tools are within easy reach, it'll be a matter of preference. Some prefer powered tools (wheels, belt grinders), some prefer bench stones. Most of my habits are built around using smaller hones that can be held freehand, so I've used appropriately sized diamond hones, blocks with sandpaper (which is surprisingly fast and effective, and as inexpensive and uncomplicated as can be), ceramic hones and strops. In the end, tight control of angle and pressure will produce the most consistent results, regardless of whichever tool is in your hands or on your bench.
Bottom line, pick a tool that seems to feel right to you, then stick with it until you know you've mastered it. That'll be 'Best Way #1'. Then try something new for your 'Best Way #2'. And so on...
There's no better 'best way' than practice (and practice, and practice).