Why can't I use the 8 inch Duo-Sharp on smaller pocket knives?
There's no reason you can't. Only thing to look out for, is a tip-leading stroke across the 'dots' on the interrupted surface of the hone. Keep the tip oriented in a direction at least somewhat away from the direction of the stroke, and you'll minimize or avoid 'digging in' with the tip, and damaging it. Whether it's the large Duo-Sharp hone or any of the smaller interrupted surface hones (Dia-Folds and other pocket hones from DMT), same technique applies. This is also a good reason to maintain
light pressure (good technique anyway, on any hone), so you don't press the tip down into the composite/plastic of the dots on the hone. All of this may sound a bit intimidating right now, but it's fairly intuitive as to how to approach sharpening on these hones, once you handle and use them a bit.
(BTW, my Duo-Sharp is an older model without the small 'patch' of continuous surface found on newer models, as mentioned earlier. I've learned to live without it, and I've found it's not that big a deal anyway. I feel like it actually encourages good technique, in maintaining a light touch and keeping the tip of the blade pointed away from the direction of the stroke. That's good for making very sharp tips anyway, so I feel like I've benefited in learning to do it this way. I use the very same technique on all of my other hones as well.

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Edit:
Another 'tip' for small blades on diamond hones: use a finer grit, even for re-bevelling. Diamond works FAST, even at smaller grit sizes. A small & thin blade is much easier to handle on an EF or EEF diamond hone, and it doesn't require much metal removal anyway, even for a completely new bevel. Simpler steels will feel almost buttery-soft on them, and amazingly slick on a finer-grit diamond hone. Much easier to protect the tips, when the honing is that much smoother. Even better with a little water, water + dish soap or mineral oil.
David