CoalDigger,
I have a Speed Bump and am also a lefty. The ergonomics on this knife are set up well for lefties. The auto assist safety lock is located between the spine and pocket clip. Easily accessed by the left hand thumb. Carry is tip down with the blade facing the rear of the left pocket. A safe set up. My only "complaint" is that the handle material has a "tacky" feel. Good in the hand but it tends to "grab" at the pocket material when drawing the knife. Blade lock/unlock is achieved by the thumd studs which are amibidextrious. For me, I favor right hand carry simply because I always use my left pocket for car keys, change and lighter. Adding a knife just gets in the way. I find the knife takes less of a beating in the right pocket. But as far as knives go, this one is set up well for lefthand carry.