I don't own either of the knives but I'm going to make an opinion based on my limited knowledge regardless.
I have a Spyderco that I just recently got, a Harpy. I've handled a lot of knives but I was extremely impressed with the quality of this knife. It is sleek, it is solid, it is shaaaarrrrrrpppp. It locks back with a nice "CLICK" and even though it is a lockback it can be closed with one hand. I absolutely love it.
I've never owned a Kershaw but I will say that I've always been interested in their assisted opening knives, such as the chive and I hear they are well made, fun, usable knives.
So it looks like I'm going to have to make my opinion based solely on looks. Which is not the best idea but it might give you something else to think about.
I like a hole over a stud, that Spyderco also looks very nice. It has a spider on the handle, I mean, come on. The spyderco's tip also looks like it will penetrate better due to the false edge. There is also a thumb ramp on the Spyderco which is nice to have for detailed cuts. The Spyderco's handle also looks like it has fine grip without the rugged feel of the Kershaw, if you are looking for smoother over harsher. Oh yeah, and the Spyderco doesn't have a big name written on the blade, which some people don't mind but I'm picky about.
Is that Kershaw a liner lock? The Spyderco will technically be more secure if that is the case, but again, whichever way you like better. Don't be scared about the one hand opening and closing with a lockback, after a little practice it comes naturally.
I just looked up the steels on each, the Kershaw has a nice steel and that Spyderco has vg-10. I noticed that at newgraham the kershaw was almost double the price. So double the price for assisted opening and g10 handles since I don't really consider the steel to be better than spyderco's vg-1o, but again, I have no experience with either knife or Kershaw's steel.
Haha, so there's my "absolutely no experience with these knives but I looked at the pictures" opinion. If nothing else it'll give you something to read.
I suggest getting the Spyderco and then buying a Kershaw Chive, Scallion, or Leek, it'll get you familiar with Kershaw's assisted opening and get you two knives. Or just buy two Spydercos

Or buy the Kershaw. Haha, good luck my friend.
-Bryan