Stretch FRN and Caly3 are two great lefty users. The new Manix2 is a great bargain of performance in that 3.5" blade tankfolder category.
Seriously tho, take a good look at the new Stretch in FRN as it's a new release and absolutely rocks. It's almost perfect in every way (even amongst Spyderco knives!). The ZDP189 model will be out soon if you would rather have it than VG10 but either knife is a lightweight ergonomic dream-cutter.
You gotta get something in a full SpyderEdge too. Maybe a Tasman or H1 Spyderhawk coming out soon (3.6" of hawkbill lovin) to fullfill the : H1 Rust Proof, Serrated, Hawkbill, criteria. If you like the Stretch FRN, it even comes in full SE!
After a few basics then it's just shameless collecting, haha.