I can't say much about the Tuff because I only handled one for a bit at a store, and realized it wasn't my cup of tea.
The Yojimbo 2, on the other hand, is one of my favourite medium sized EDC knives, quite an improvement on the original one (which I love as well). Great steel, great lock, excellent ergonomics and a decent price. The blade/handle ratio is much better than on the Yojimbo 1. I wish it were flat ground, though.