As far as combining stuff, yea, people have explosive bonded Ti and S30V. I don't think it would be an issue combining the steels you mentioned. IIRC, Chad Nichols even made 3V/XHP damascus.
I'm not sure the properties of each steel would be cumulative if you powdered all of them, uniformly mixed them, and finally HIP them into a bar for making stuff.
Besides that, 3V (or similar derivative, 8% Cr steels) has roughly the same toughness as both L6 and 5160 at similar hardness (59 HRC, 40-50 ft/lb). There's also steels like Z-Tuff which would have similar toughness even at a couple points higher in hardness (62 HRC, ~45 ft/lb).
I think S5 can reach 100+ ft/lb at around 60 HRC (max attainable hardness is 62 HRC). However, I'm not sure I've seen many edge retention test, if any at all.
I could see a Damasteel-esque non-stainless with 3V/S5. That would actually be kinda cool. However, it would probably be more of a cosmetic thing than an real gain in performance in any one category.