I have a couple of Buck folders handled in stag. The covers were just glued on, and not pinned. No issues at all, where I originally bought them and lived for many years in central Texas - the relative humidity was fairly high most of the time there, at 40-60% or higher. After 20 years there, I moved back to my native New Mexico, where the climate is a lot drier and relative humidity at/below 20% most of the time, and sometimes down to single digits. Hadn't been here long, before I pulled them out of storage one day and realized the covers on both knives had warped pretty severely, leaving big gaps under the ends of the covers. One of them was bad enough, the warpage had separated the glue from the handle, and the covers actually came off.
So, moral of the story is, watch out for prolonged and severe changes in humidity, with natural handle materials like wood or stag, at least. I don't have any in horn, so I can't speak for that - but I take others' word for truth on that. I've never had any issues with bone, at all, no matter where I've lived.