Good Question and tough one at that. There are so many variables that go into this question. Are we talking about just the toughest design overall....??? The one least likely to break under use....??? The toughest Lock....??? etc...???
The blades. The thicker blade would be tougher to fail than a thinner one in my opinion. Some may argue that a thinner blade will flex more before failure, while a thicker one would not. I believe the high RC of these steels, any flex would be a recipe for breakage, thicker or thinner. The thicker blade of the 25 is pretty impressive. The grind on the zaan would also add in its strength. If any of the blades would be prone to failure, I would imagine the 21 blade because its thinner near the point and has a thinner edge.
The blade pivot: I realize that all of these have slightly different blade pivot screws. The regular, classic, 21 are the same, while the zaan and 25 are beefier. In all fairness to them all, I would rate them as equal because with the blade being sandwiched between the scales, all of the design should be at equal strength. It is possible that the zaan and 25 would fair better because you have more of a head or cap on the heads of the screws, so if there is an edge, I would give it to them.
Blade Lock: My belief is that the older design would be the strongest. That being the traditional lockup of the regular, the 21, insingo, etc. On these, you have the flat blade tang mating up with the flar lockbar end...You have a large flat on flat contact area, no blade play. Its about as strong and perfect fit as one could ask for. The 25 and the zaan have a ceramic ball lockup which basically locks up on a point contact area. It has proven to be super strong tough. But in theory, I would go with the older versions.
Overall: I own and have owned many CRK. I have had regulars and zaans that I have put through some pretty extensive paces with no issues. The 25 get carried lots now, but its still relatively new to me. I have yet to get an insingo, but it is indeed on my list to buy.
In the end, I find it hard to imagine you would damage any of these under normal use and used for what they were designed for. Folding knives are designed to CUT. Not to be used as a prybar, as a hatchet, and God knows what else some throw at them.
If I had to pick some that I would feel more confident in than others, I would have to go with the 25, the zaan, and the regular as I have had the most experience with em. But I must say that I would take any of em with me any time any where on any adventure....!!!