Spyderco makes very good usable tools. Good tools can cut flesh too. Any spyderco can cut flesh. For defensive action, you need to be able to cut flesh and jeans. All spyderco's qualify as very good defensive tools.
Even a well place 2 cm deep cut is good enough to turn any attacker down, so size is not really relevant when cutting.
If you want intimidation or stabbing, you need size. Go with the police, calypso ,endura , starmate, viele, herbst.....
In general, if tactical means large, these are good all good choices.
Off topic....what do you define with tactical?