Drilling is the easy part. You need a drill press, and a drill bit of appropriate diameter and material based on the metal you want to drill. All bits are not the same. For example- if you are drilling stainless steel, I would recommend a carbide or carbide-tipped bit.
Hardened steel can be drilled using a carbide bit, but tapping hardened steel is a whole other matter. I wouldn't even try it.
Tapping stainless steel can be tricky/difficult even if it isn't hardened. And the smaller a tap is, the greater the chance it will break.
If it's titanium you want to drill and tap, I have no experience with that, but from what I hear titanium is more difficult to work with than stainless steel.
If it's brass or aluminum you want to tap, they are much easier. But again, tapping straight can be tricky/difficult. If you get it wrong, you can't re-tap that same hole with the same size tap. If you don't keep the tap straight you can wind up with a screw that threads in at an angle.
If you are set on drilling and tapping some holes, and if you are not experienced doing so, then I would advise finding someone who is highly skilled and experienced at doing so with the material and screw size you desire.
Also, there is more than one way to attach a clip to a knife. Tapping is not always necessary. One method is to drill the holes all the way through, then countersink the holes on the side of the liner or bolster opposite the clip side using a V-shaped countersink bit, then use V-head screws, run the screws from the inside out with the threaded ends of the screws sticking out of the clip holes. Countersinking the holes will allow the heads of the screws to seat flush with, or lower than, the surface of the liner or bolster depending on how thick the metal is and how deep you countersink the hole. Then secure the clip with nuts and locktite on the screws. After securing the clip with screws and locktite the ends of the screws can be smoothed out using a dremel with a sanding attachment, or a fine file, and then a coarse buffing attachment or sand paper.