Atomic Zero,
It's the size that makes it a bit difficult, but then, I have very small hands also. If you have medium or large hands, I'm pretty sure it would not be much of a problem at all.
Just to clarify, when I say hard to manipulate with the left hand, I'm referring to closing the CQT one handed, much as you would close it with the right hand...IE, manipulate the liner with the thumb and then use the index to push the blade closed.
I can close it left handed once or twice, but that's about it, for about an hour or so. So actually, it's not even a problem with the left, unless you are just cycling it repeatedly.
Also, moving the liner lock out of the way with the left thumb and then using your leg or some such for assistance in closing also works nicely, but it does not look as fancy, if you know what I mean, although it's still a one handed close.
Opening is totally ambidextrous, due to the thumb disk. Although the left side is not relieved, opening with the left thumb is still easy and secure.
Does that help any? The CQT is a fantastic knife, and worth every penny. If you are looking for one, I would suggest Patrick at
http://www.s4supply.com .
I don't work for S4, and am in no way affiliated, I'm just an extremely satisfied customer.