Much as we don't like it, the synthetics have it all over the natural handle materials in hard use situations. That Buck 301 stockman I used for about 25 years, including years of army engineers duty, still had the Delrin handles in good shape. The knife was sent back to Buck several years ago to have the main blade replaced, but other than that it's good. If you're looking to a handle for hard use in all climates, delrin is great stuff, as is micarta.
BUT!
Don't sell the mother nature issue stuff short. The wood handles on a 1960's era Buck 110 and Gerber folding sportsman 2 are in good shape. Wood like cocobolo, ligna vita, rosewood, are exremly dense and durable. True some of them will darken with age, but so will saw cut bone like on the old barlows.
Keep in mind, that bone will last a long time. Digging up civil war graves for research turns up skelitons with the bones laying there for over a century and a half. With a little care natures materials will last for your life time, and after that, does it really matter?
Stag seems to be the best of the animal materails. Especially the India stag. A century of use just polishes the stag to a creamy smooth finish of dark honey gold. My grandads stag stockman is still in decent shape for carrying, and that stag is circa 1940's. His seamans clasp knife he bought in a ship chandlers shop in Sligo Ireland in the early 1920's, has stag handles, and so far they have no cracks or chips. But then I recall grandad used to rub a little oil into the stag stockman, so he may have taken a bit of care with his seamans knife as well. But 80 years is a good record for durability.
I think it all boils down in the end as to what you want. Maintance free unconditional service synthetics, or natural beauty that ages with us but may need a little loving care now and then with a bit of mineral oil rubbed in.
At this point in life I like a knife that has aged along with me. Maybe its the peace I've made with the knowledge of a finite life span myself, so I don't mind if my gear looks a bit as aged as its silver haired owner. It all comes down alot to you philosphy on life. Patina is good. It better be, I'm patined as heck.