Anything more expensive than $400 ish and I'll be constantly worrying about losing it, so much so that I'd prefer not to carry it. Most people seem to push their price limit higher and higher as time goes on, but I've done the opposite. I used to be willing to spend big bucks on a knife, but now I cringe at anything over $250. My good ol' Caly 3.5 with G10 and Superblue is, for all practical purposes, the perfect EDC. I use it for everything. Fancy steels, fancy inlays, carbon fiber.... blah blah blah, whats the point? A knife is a tool. As soon as you hesitate to use it or carry it, it's no longer as useful as it could be. You're on the wait list for months and pay big bucks for your new Joe Blow custom with carbon-timascus-glow-in-the-dark inlays and CPM's latest high speed steel.... ect. Finally it comes and you're stoked. Are you then going to EDC it and wip it out to open a bang of gravel without a second thought? I doubt it.
I get the appeal of quality goods made by master craftsmen. If you're a collector, then by all means go for it. But I don't see any practical point to expensive knives anymore.