I like to wash mine regularly with soap and water, and then re-oil. There are many good oils, bother to get a good one.
I use my knives for food regularly (& as discretely as possible

) so periodic washing is healthier.
Light sharpening often is best, IMO. I usually hit my EDC on the Tri-angle (30 degrees) a few strokes each day, or until shaving sharp.
We've built a few collector pieces but most Spydercos are hungry and like to eat. As mentioned, open, close, cut, clean, oil, cut, cut, cut...
To a Spyderco, that is living.
All of the effort that we put into designing and building the knife is found in using the knife; The horsepower in the steel, the edge, the ergos, sophisticated mechanisms, carefully chosen materials or custom made materials, history of and refinements to the design, etc.
Letting it die in the box is to lose 75% of what we put into it.
sal