The exact methods used to acheive the desired results are almost certainly proprietary, but Sal has shared the "basic physics" with us on more than one occasion.
He has said repeatedly that a properly constructed and maintained front lock, unless defective, will never fail at the lock. They fail when one of the two pivots, either blade or lockbar either shears or bends and tears its way free from the handle.
Since with Spyderco we can take "properly constructed" as a given, that would lead one to think that the size and quality of pivot material, and the thickness and strength of steel liners when present (as is the case with the Manix) would be the major factors in lock strength.
Another major point he has often made is that, for obvious reasons, it is more desirable to have a "graceful" faliure, the type that occurs when things first bend and stretch then pop apart, rather than a sudden catastrophic one, as occurs when a part suddenly "snaps".