Depends on how/what/where I big game hunt but... for cutting pepperoni and cheese at the card table, kitchen and camp use and field dressing skills, if I were limited to one knife I would take my Puma White Hunter II with Kraton handle. The back-side can chop light brancges or make kindling and the blade shape is good for skinning.
I usually carry two knives, a folder and a one-piece, with the former for cutting and the latter for tough stuff and hard use. Overall, a skinner or semi-skinner os preferred and the White HUnter II, or White Hunter (full size) with small serrated section foots the bill very nicely, thank you.