cevtv/singularity35 - remember what Sal says about shiny foot prints? =]
You both are passionate about knives, you both do training, you both worry about opening the knife under stress, and you both are smart enough to buy Spyderco folders, and patient enough to get your hands on the mythical Yojimbo 2. That's a decent amount in common to start a positive discussion. =]
Singularity35 - Janich is a master of inertia opening. I believe he states it as 'his' (personal) preferred method, but not everyone will spend the time learning it. I'm willing to spend the time, but I can't figure it out as of yet (yes, I need slow, okay s-l-o---w motion video and instruction).
I usually flick open the knife, and that's mainly how I've opened my yojimbo 2 since it came in on Saturday. Bought one the minute I heard there was going to be trainers.
If you don't want to flick it, you should be able to stick your thumb body (the pad part) into the hole and 'shoot a marble' and it should open pretty quickly and easily that way. Should not require a flick of the wrist, which I think is what you are worried about... if your hand gets hit while you are making the movement, you are worried about losing the knife.
It's good/great to be thinking about such things and the venerable Kelly McCann (Janich's friend) addresses that concern during his Crucible knife video. Janich likes tip up (Yojimbo 2

and McCann likes tip down. Who is right? Personal preference, pro's and con's either way, depends on the individual and I wouldn't get into a knife, fist, or gun fight with either. And while they are both hard asses, I doubt either of them would be uncivil with each other while arguing their points
Don't know if the thumb-pad-shoot-marble helps, don't have a good way of doing videos currently.
Janich is going to have a video on knife openings coming out via Staysafe in the next couple of months. Might be useful.