Well, the knife came in about a week and half ago and I've been carrying it ever since. Here's come thoughts:
Fit-and-finish: I had the great folks at Knife Works hand pick a nice example and it certainly doesn't disappoint. Grind lines are clean. Came perfectly centered. Really solid lockup, but if I grab the blade by the very tip I can detect a little side-to-side wiggle, but it's almost unnoticeable and isn't a big deal at all. All the internal components are crisp and nicely-machined. The screws are all flush with no surface imperfections or stripping, and they all came Loctited which is a nice extra from the factory and saves me time from doing it myself. Overall the knife is extremely well-finished and I couldn't be happier.
Design: Right away, it struck me as a very unorthodox design. It took me about half a day to warm up to the ergonomics, locking system, and overall idea of the knife. At some point something "clicked" and it all made much more sense. It's really a design you have to get in your hands and use to fully appreciate all the fine details that went into designing it. Although this is first and foremost designed as a fighting knife, but it fills the role of a utility knife very well. The Wharncliffe style blade isn't at the top of my list for utility designs (I like some belly to my blades), but it should accomplish most tasks that I ask for in a knife.... a kitchen knife, this is not.

This is currently the smallest knife in my collection, as I prefer larger knives like the Military, Chinook, Manix 2 XL, etc., but it sure does fit a lot of blade into a relatively small handle. I love hollow grinds, and this one is ground nice and thin, although ascetically I would have preferred a flat grind like on the original Jojimbo.
Ergonomics: The ergonomics seemed a little weird when I first got the knife, as I'm used to bigger blades. For reference, I have about medium-sized hands. There's 2 main ways I found myself using the knife: the first is placing the thumb on the jimping at the front of the handle and allowing my fingers to fall into place. The groves cut into the handle are very well thought-out and placed in the correct areas, although there's not a lot of surface area near the rear of the handle, and while I can get all four fingers on the handle, I found my pinky looking for a little extra gripping area when placing my thumb on the jimping on the handle. The other way to hold the knife was the intended way: thumb on the spine of the knife. It fits like a glove in this position and it feels most natural this way. The blade stock is really thick and makes this grip very comfortable for the thumb. A little extra handle length would have been nice, but I know they tried to make this design as small as possible while maintaining the original design intent. Overall, ergonomics are very good for a smaller knife.
Locking mechanism: The Compression lock is one of my favorites, due to it's simplicity and robustness. The tolerances have to be spot-on to get the locking liner to nest properly between the lock face and the stop pin. It's a fun locking system to play with, as I've probably spent more time opening and closing the knife than actually using it.

After applying some Militec-1 to the pivot, the blade drops and swings freely when you have the locking liner disengaged. The tension on the lockbar is really, really strong. This makes for a great detent - no matter how hard you shake the knife, there's no way the blade is coming out. Overcoming the detent to open the knife was a little difficult when I first got it, but after lubing and flicking the knife open probably several hundred times, it loosened up to where it's very smooth. Lockup out of the box was about 30%, and it hasn't moved at all. Very happy about that and a testament to the tolerances on the locking mechanism.
Materials: CPM-S90V is a stainless tool steel with extremely high wear resistance. I don't have a lot of experience with the steel, so I can't comment on edge retention yet. The edge from the factory was "toothy" and would hang when slicing copy paper, but only a handful of swipes on a ceramic rod had the knife screaming sharp. Very reassuring because I know how hard some of these super steels can be to sharpen. Peel ply carbon fiber is my favorite material for knife handles: it has the coolness factor of carbon fiber laminate combined with the grippy texture of G-10. The carbon fiber pattern looks mesmerizing in certain light and is also very utilitarian, being lightweight and extremely tough. Top shelf materials on this one.
Clip: This is a ridiculously strong clip, mechanically-speaking. I noticed a small gap below the screw holes when placing the knife horizontally near a light source (if that makes any sense) and OCD got the best of me. All I needed to do was slightly adjust the angle of the top of the clip to get it flush with the scales, and this thing is really, really hard to bend. It took my about 5 minutes and lots of force to slightly adjust the angle of the top of the clip. Now it sits completely flush with the scales, and this taught me that this clip design can take a lot of bending force with no real degradation to the tension. Cheaply made clips bend very easily, but Spyderco put a lot of effort into getting the heat treat right on these hourglass clips. The tension is really good, not too strong as to make the knife hard to draw from the pocket. I ended up converting it to tip down carry because I did not like the fact that there isn't a lot of surface area to grab when the knife is configured to tip-down carry. I'm a lot happier with the tip-down configuration and the clip doesn't bite into the hand or make the knife feel uncomfortable when gripping it.
Overall impressions: Highly recommended. You get a lot of knife for the money. Premium materials, fantastic design.