Just remember that the end product will only look like a brown/grey block when you sand it. It will not look like a leaf.
Agreed. Leaves? I wouldn't even bother.
As the other fellows have said, the fibrous nature of the substrate is mainly where the strength comes from in micarta or G10 (or plywood, for that matter... specifically because plywood is built so each layer's grain runs perpendicular to the ones on either side of it). Laminated cloth and fiberglass have similar or greater strength, partly because they're woven and have fibers going both ways in every layer.... I don't know of any leaf material dry enough to absorb resin that has anything like the fibrous strength we would need in a handle.
If one wanted to encase a single cool-looking leaf in clear resin, and use that for a scale, that's a different story. Back in the day I knew a few cats who wore certain small leaves of a very specific plant

encased in amber or acrylic as pendants... Durability would depend mainly on how hard/tough the resin gets when cured. The leaf (or bug or whatever) will have very little to do with that.
About 10 years back, a fellow decided to make dollar bill Micarta. He took 100 dollar bills and laminated them as a block. Upon grinding all he had was a $100 mottled color handle.
Right. As for repeating patterns in a scale of homemade MyCarta... good luck. In order to get that pattern to be consistent through the piece when it's shaped and finished, every layer has to be the same and
very tightly registered. This works OK with a stack of business cards or letterhead; not so much with a stack of leaves or even layers of camo cloth or dollar bills. You might get the portait in the middle and the borders to line up pretty well, but the serial numbers are going to become a blur. Not to mention, the printing on the backside is going to look weird between each layer...
I had zero success making birch bark micarta slabs a couple years ago. I've tried both "complete" bark (white papery outer layer intact) and "peeled" bark (white papery layer removed). I was mostly looking to get that gorgeous white and black look on a knife handle.
It was pretty as could be, and would possibly make a nice plaque or clock or something, but it had no strength or integrity at all. (I think) due to the oils in the bark, it never cured up properly and was easily bent, twisted and peeled apart by my
then-11-yr-old daughter.
If a little girl can tear it apart, it's definitely not going to hold up on a knife. Basically useless as a scale on a full-tang knife.
However, stacked "peeled" birch-bark on a hidden tang makes a
really good-looking, comfortable and durable handle! Being sandwiched snugly between some sort of guard/bolster/ferrule and a pommel with a steel "spine" through the middle of it gives it excellent mechanical integrity. The natural oils keep it soft-to-the-touch (but not mushy) even in cold weather, resist moisture absorption and greatly reduce chances of shrinkage and rotting. I'm told that BB handles last
much longer than leather handles made the same way, and while I haven't proven that myself, I lean
very strongly towards believing it.
Sorry to be discouraging; I'm just sharing what I've found through wasting a bunch of time and materials on this sort of thing
