Agree with Buffalohump on spine whacking. What sort of cutting task might come up where this would be a factor? Most of us have used slip joint knives since we were kids and any cuts we got weren't from the knife folding up on us. If that happened our Totin' Chip would have been pulled. I view the lock as simply a bit of insurance against the knife folding when you don't want it to. If you have a reasonable expectation that it would fold if it were a slip joint, then you should be using a fixed blade, IMHO. That said, pick the one that is handiest for you. Seems like the Spyderco hole outweighs the small thumb studs in this case, for you.