52100 is wonderful stuff! It has high toughness and good edge retention all across the normal range of hardnesses we expect from knife blades... since it has such a nice internal structure, I see no reason not to run it on the harder side (60Rc or perhaps even higher) to get the most wear-resistance while still having a good tough blade. Its fine grain helps it get very crisp, sharp edges pretty easily. It works really well in everything from custom straight razors to thin, small knives designed for delicate work to chef's knives to big ol' choppers meant for rough use.
Top-notch HT is naturally a must to get the most out of it, but that's not as tricky or "magical" as some people would have you think. Corrosion-resistance is low, but so what? Keep it clean and dry, perhaps with a bit of oil on the blade, and it will outlast all of us. :thumbup: