I don't have much experience with a leather belt on a 72x2, but I would run it Slow.
With such a fine abrasive, and with as much contact you would have, heat generated through friction would very likely be high.
^this
Even if you run it as slow as you would stropping by hand, heat is going to build up because there is no pause to lift.
It's easy to get an edge sharp through powered tools, but just because an edge is sharp doesn't mean the apex is full hardness and is going to stay sharp. It would be a shame to run high end knives as hard as we do in pursuit of edge retention, and then draw back the last few thousandths of an inch of the edge sharpening it.
The edge angle, the conductivity of the alloy and the tempering temperature used all affect how far back that heat affected zone goes back. If it's half a tenth of a thou who cares? If it's ten thou you have a big problem.
A thick rough use knife in A2 is going to be little danger because it keeps good hardness up close to 1,000 degrees, it doesn't need to hold a very sharp edge so if a few thou of the edge is soft it won't be noticeable and it has a higher coefficient of thermal conductivity so heat doesn't build up as much as higher chrome steels. A thick edge has thermal mass behind it to help keep it cool. Some knives like that will tolerate some carelessness sharpening.
A thin stainless steel kitchen knife at HRC 61 tempered at 400 degrees is going to be a much different story. You'd need to be very careful with something like that. Remember, you can't see minor heat damage in the edge with your eye, it shows up in use.
I make hundreds of knives a year, most of which fall between those two examples and they all need to be sharpened. I wish there was a safe shortcut but my own testing revealed to me that there isn't one. You need to be very careful with powered sharpening of any kind. It is a necessity, but without testing your process you're flying blind.