If you look at the handle material under magnification, you'll notice that bone, stag and wood have both pores and grain. It's especially noticeable in the ends of the scales (like end-grain on wood), if you can see that on the handle material. It's also sometimes visible in the inside edges of the 'jigging' also. This, at least, should differentiate natural material from synthetic (like Delrin/nylon/staglon).
I'm a fan of Case knives, in particular the '65 pattern folding hunters. I get a kick out of all the eBay listings I've seen for the 6165/6265 folding hunters with wood handles that are described as bone handles. As mentioned earlier in this thread, there's definitely an 'experience' factor in being able to determine which is which at a glance. The actual bone handled knives tend to have more of a high gloss/sheen to the finish (more so with age), whereas the wood handles don't ever seem to quite get that glossy. The bone handles, at times, almost have a 'liquid' look (with depth) to them, especially when viewed under strong light. It doesn't help that Case, in their own documentation and pattern-numbering scheme, identify any jigged handle material (wood, bone, or occasionally jigged delrin) with the '6' as the 1st digit handle material identifier in the pattern number. And in the case of the more recent wood handled knives, most of them are laminated wood. You can see the layers (like plywood), if you look at the edges of the handle scales under bright light with magnification.
As mentioned earlier, a little bit of HOT (like a needle or soldering iron) will immediately betray a synthetic material like delrin (it'll melt). Obviously though, that's usually not something you can do when inspecting someone else's wares at the knife show. But, if you've got some of your own that you're not sure what they're made of, it might be worth a try.
And to me, the synthetic materials like delrin or nylon are soft, compared to bone or stag, and can be scratched easily with your fingernail.
Edited to add:
I've noticed also, with dyed bone handles, if you take a rag/paper towel/Q-tip with a little bit of solvent on it (like rubbing alcohol or WD-40) and rub the handle material, some of the dye/color in the bone will come off, especially from inside the jigging. It's very apparent with new knives, usually rubs off quite a bit of the dye, sometimes even without solvent. I've never seen this happen with a synthetic handle material (it's color is intrinsic to the material itself, so it stays put).