Sure it is. Lots of manufacturers send out liner locks in tip down carry or make them only for that mode of carry because its considered safer. Not sure I agree but gravity can do strange things.
I had a liner lock custom in my shop the other day for work with a stripped screw that the maker either didn't fix right after two tries or just didn't want to do not sure. Anyway, the point is that someone, not the current owner because he didn't know about it, but someone took a dremmel and grinding wheel or sanding drum to the detent ball on the lock and sanded it flat so it didn't even work at all anymore to help prevent the knife from opening by gravity. Essentially they made it a better flicker I guess. Its not anymore though because I fixed that too after discussing it with the owner.
How a knife behaves in the pocket can be hard to predict. Moving, lifting your leg up or bending down in a stooping position can all do any number of things when you squeeze things tighter in your pant pockets. If the knife is in the pocket mixed up with some keys and you scruntch down it can even open the knife from one of the keys pushing up under a thumb disc (personal experience) and I've even had some flipper types for right hand tip up carry open on me when I did that while carrying a right handed knife in my left front pocket, but not all the way. It was just enough to know it happened.
Liner locks with weak or non working detents are subject to some opening problems probably more so than other types but I'm sure none are exempt. Detents that are not set right where they catch the blade but allow it to lift up enough to expose the point out the end can catch clothes and other things and cause the blade to open also.
Get to know your knife. If it seems too easy to open some adjustment to the pivot can fix it real quick in many cases.
STR