My thoughts, for whatever they're worth...
Been shooting a 10/22 for many years now. It's a good gun, accurate, sound, and fairly reliable. It does need relatively frequent cleaning or it will start jamming. The BIG benefit to the 10/22 is that there are TONS of aftermarket accessories for them, and you can build one up to about any rifle you can dream of. The base rifle isn't very expensive either.
Just recently bought a CZ 452. I like this rifle more than the 10/22, personally. Much prettier, handles great, is accurate as I'll ever need a 22 to be, and is a very sound gun. It has a very simple action that seems to be very solid. The stock trigger is much, much better than a stock 10/22 trigger as well, which counts for a lot in my opinion. It is quite a bit heavier than my unscoped wood stock 10/22. I like the sights on my 452 a lot more than the stock Ruger sights.
In the end, I shoot the CZ much, much more now. It's more fun to shoot with the bolt action, which keeps you from just spraying ammo downrange. The habit of "spraying" is easy to get in to with the 10/22.
If you're into lever guns, the Marlin 39 is a really great gun. Going to own one someday. Problem is, they're getting really darned expensive. I've shot a couple Henry 22s and they seem to work pretty darn good and are a lot easier on the wallet.