Yeah, I've asked questions like this before.
The basic criteria for evaluating any knife locking mechanism could be summed up this way:
1) Ease of opening
2) Ease of closing
3) Lock strength
A) Against pressure applied to blade spine
B) Against impact on blade spine
C) Against pressure on edge
D) Against impact on edge
E) Against lateral force applied to blade or handle (think: prying)
F) Against lateral shock applied to blade or handle
G) Against twisting force (try reaming a hole out with your knife and you'll be doing this)
The way that I would go about evaluating a lock's ability to hold is to look at the strength of the parts which are actually going to resist applied force.
As an example: a linerlock transfers the force of whatever you do to the blade back through the liner slab. Now, there are some insanely thick liners out there, but many of these have a substantial amount of steel milled away at some place to make a kind of pivot point. It is here that the lock is most likely to fail.
The answer to your question is going to depend on what you are cutting, and what from direction you anticipate the majority of force being applied to the knife. You can then choose a lock mechanism which resists most strongly from that direction. Most locks, obviously tend to favor the sharp part of the blade.
The real answer to your question is: what knife do you like in the price range you are able to pay?