I own both an Emerson LaGriffe and a Microtech Medallion. I like 'em both, but for different reasons. My Medallion is now part of my EDC rotation and my LaGriffe is my number one choice for an "oh sheet" knife. Let me explain....
I like the utility of the Medallion and found after carrying it as a necker, that I liked it better clipped to my belt with the Tek Lok. IMO the sheath does not make it easy to deploy from the neck. You have to move it up in the sheath to get it out. It handles well for utility tasks, and being that I have average sized hands, it fits comfortably in my hand. If my hands were larger, I might be thinking differently. I do not feel the Medallion is MY best choice for self defense. With my skills (or lack thereof), the smoothness of the handle and the size of the knife overall, I'll bet someone could take it away from me fairly easily when I needed it the most. I like it for EDC for its utility and shape.
The LaGriffe is a a great design for self defense. Light, simple & effective blade, great sheath, and with your finger in the hole you are one with the knife - it is attached to you. It's design makes cutting very efficient, and I would not be concerned about the blade length. As stated in a well-known review of this knife, "flesh compression" (hope that's right) makes it effective despite its length. I love my LaGriffe and will not part with it...or rather can not be parted from it
For just a tad bit over $100 (approx. $20 more) you might want to take a look at the Busse Assault Shaker. To me it looks like the perfect cross btwn. utility and self-defense, but I'll know more later this week when mine arrives.
I just sold my Boker Bud Nealy to help pay for my Busse AS. Although it felt comfortable in the hand, I was always concerned about my index finger coming fwd onto the blade if used in a push motion. The sheath in the necker configuration was not comfortable to me either. The knife saw no use or carry, but that's just me. Your mileage may vary.
If I could pick just one? Emerson LaGriffe.
Edits - My usual spelling & grammatical goofs + info on my use (or lack thereof) of my Boker Nealy collaboration.