I assume that the blade is a hidden tang, and when the glue dried the handle was cocked off to one side a bit?
Photos or a good description that will let us know the tang type, handle material , and any other pertinent details are needed to make any answer.
Some ways to avoid and/or deal with this problem are:
Use a gluing clamp, which allows the handle and blade to be kept in alignment ( which is too late for this knife). Make one from a woodworkers clamp. Saw a 1/4" wide and 3" long slot down one jaw for the blade to slip through. The guard will sit against this jaw. The butt of the handle will be held tight with the other jaw. Because the jaws can be angled any way you wish ( by adjusting the two screw handles), the handle can be easily held so the joint at the guard is perfect. Here is a clamp of the type I am speaking of:
http://www.woodcraft.com/Product/2020512/22601/Pinnacle-Handscrew-Clamp-8-inch.aspx
Use a slightly oversize block of handle material, and after the glue is dry, grind/sand the handle so it is in alignment with the blade. This is always a good idea. On the current knife, if there is enough material ,carefully remove material from the back of the leaning side and the front of the other side to make the sides parallel to the blade. Then shape the handle the rest of the way. You may have to taper it a bit or something to make it look right.
Un-glue the handle. If the material isn't extremely fragile or heat sensitive, you can warm the knife and make the glue break down. Place the knife in an oven at 200F. Using gloved hands, after 10 minutes try and see if the blade can be wiggled any at all. Twist it and wiggle it, as if you were working a fence post out of the ground. If it doesn't move, try the oven for another 10 minutes. It may take as many as 30 minutes for any results to show. If it still isn't moving, raise the temperature to 250F and try again. In many cases, you can heat the blade with a heat gun, or carefully with a torch, and raise it to about 300-350F . This will destroy the glue joint and allow the blade to be pulled out of the handle. Done carefully, it will not hurt the blade or the handle. The handle can then be drilled out to remove all the old glue, and re-glued straight.
Take a hammer and smack the handle while holding it on the anvil. This will remove the handle. Clean up the tang and start with a new handle block.
A tip on avoiding this problem is to make sure the handle block sits perfect on the guard before gluing them together. After drilling out the block to fit the tang, sand the block end so it sits perfectly flush with the guard/bolster. Clamp it in the jig and look it over all around. If it is a perfect fit and all is straight, take it out, glue it up, and re-clamp it.....checknig that all is straight. When the glue is almost set ( check your unused glue for tackiness), double check everything - things move sometimes . Make any adjustments NOW, as the glue will be set too firmly in a few minutes.
Also, slightly chamfering the tang hole makes it easier to fit to the guard, as there is no material touching in the center, just around the perimeter. This trick can help make a seamless joint.