For me, price holds more sway than handmade vs. production. If I'm paying top dollar, then I want as close to perfection as I can get, regardless of how the product was produced. If there are quirks, I see them as flaws that should not be there, given what I'm paying for.
On the other hand, production-line imperfections, such as can be seen on the Victorinox Alox models I have (gaps here and there, some tooling marks, differences in spring tension from one knife to the next) are fine with me because the price of that product is so low given the quality you get.
Similarly, my GEC Scout's Bocote wood scales are slightly different one side versus the other. That kind of bothered me at first, seeing the unevenness. But I love the knife so much that I don't even think about it anymore. And it cost me well below $100.
Does it add to my liking the knife that you can see evidence of hand-craftsmanship? No. I'd just as soon have the scales be symmetric.
Would I like the knife less if the scales were done entirely by machine? No, because the inherent design of the knife is so much to my liking.
That said, a big selling point on GEC knives for me is the fact that they are made on the same machines that cranked knives out decades ago. To me, that adds as much charm as being entirely handmade.
EDIT: I very much agree with what NirreBosse said, too. But I don't agree with Knifehead that it's "bad form" to compare handmade and production products. People should feel free to compare whatever they want without concern for hurting the egos of those who paid 10 times more for a product that essentially performs the same task.