The Cent 4 is perhaps my favorite Spyderco for EDC. It is just such a well thought out knife. I use a Lansky so I can't help you on the Sharpmaker but I suggest going as much as 20 degrees. It sounds like a lot but it is a thin blade and will only help to slice things.
As you know because you have one, the Cent 4 is thin and light with a thin blade. It makes you think that it is weak but it isn't. There have been times when I have used my Cent 4 much harder than I would have wanted only because it was the only knife I had on me at the time. That is one thing about the Cent 4, it WILL be on you when you need it. Your Manix may do a better job at heavy cutting chores but only if it is with you. A Cent 4 in the pocket is worth more than Manix at home in the drawer.
My point is, it is a very strong knife despite it appearance of weakness. Use it hard and I think you will find that it can take. There is just something about FRN and VG-10 that wants to work!