My personal opinion is that CA alone would be the least desirable for knife handles. Heat, cold, and shock can easily break the bond. Combined with mechanical fasteners, it MIGHT be viable.
For several years I used 2 part epoxies, but after having several knives returned with "loose" handles, I started doing some research and found that most of the commercially available 2 part epoxies are specifically engineered to start breaking down after about 5 years. Further more, their shelf life is approx. 6 months from date of manufacture. That information came to me directly from a chemist who worked for a well known epoxy producer. When I told him I was shocked to hear that, his reply was...."We're in the business of SELLING epoxy, why would I create something that lasts forever?" "I want you to have to buy more of our product!"
After searching around an trying various things, I now exclusively use Brownell's AcraGlas. It has a 10 year shelf life, and a guaranteed hold life of 50 years, is totally waterproof when cured. Another product that many knifemakers use and love is West Systems Marine epoxy. It's shelf and hold life are slightly less than AcraGlas, but otherwise the two are near equals.
If you intend to be a knifemaker for very long, it's in your best interest to use the best materials possible for the given job, including adhesives. If you cut corners on adhesives, you'll have people hunting you down in 5-7 years with issues for you to repair. It won't matter if you used the best steels and/or handle materials...all the individual will care about is that the knife you gave or sold them is falling apart.