For defensive purposes, the only advantage to the chisle grind that I can see is that it may decrease the amount of friction on a blade. Sorry for the very untechnical answer! I have an article in a book where Phil Hartsfeld has a little piece of wood with a slot cut in it. He places business cards on the block and pushes a Fairbairn/Sykes dagger and one of his (much wider/longer/thicker) tanto blades through a card as well. THe Hartsfeld blade is chisel ground. He demonstrated that the "points of contact" were much less on the chisel ground blade than on the dagger, so it would puncture more easily.
That said, I do not know if chisel ground really makes all that much of a difference. Many people are stabbed to death each year by screwdrivers which must be harder than a F/S dagger to stab a person with. Chisel grinding may make some difference, but my gut says that is is quite minor as compared to other variables to play with, like blade width or blade length.