The 44 mag version is a really sweet one to shoot. Very accurate, mild recoil, great cool factor at the range. 44Mag is a lot cheaper then 50AE so, you can actually afford to shoot the 44Mag a lot.
Not something you buy for hip carry walks in the forrest or, self defense outside the house though. If I only had a handgun, needed that kind of power, accuracy and range, a Desert Eagle could easily get the call. That polygonal barrel and lack of barrel to cylinder gap combine to boost the ballistic efficiency and, in my guns, the accuracy. I can literally shoot the nails out of the target frame accuracy-wise. Then you've the power and range of a 44Mag at plus levels thanks to the barrel.
If I needed something to walk around with in a self defense type of scenario (Alaskan bush pilot or similar), I would opt for a Freedom Arms revolver in 454 Casull.