Well, I haven't spent enough time with the 2x72's to say which is the best for me, but probably two or three 2x72's with big motors and independent VFD's. That way I can leave one or two setup for specific tasks I do over and over and then have one for the tasks that involve changing tool arms or reconfiguring a platen or wheel constantly.
A good surface grinder well suited to knife making sized stock.
A couple mid sized disk sanders, 10-12"
A 2x72 horizontal grinder, or just a good setup for one of the other 2x72's, it's the capabilities, not the specific tool I would like to have.
Two double sided buffers, for a total of 4 wheels, just saves time changing out wheels to use different compounds.
Sand/media blasting cabinet.
decent sized compressor. I don't use compressed air much, but between the blasting cabinet and occasional other uses it's nice to have a big tank. I don't need it to fill up real fast but a 40 or 60 gallon tank with a reasonable compressor would be nice. This would be plumbed in so give outputs around the shop.
I'd probably want the above in a fairly contained area, it doesn't need a ton of extra space since I'm only using one tool at a time, I don't need elbow room for the guy next to me, just enough that each tool is not interfering with the use of those next to it.
A hand sanding station with some flat plates, sanding blocks, cubby holes for different papers....
Storage for belts where I can hang each particular type and grit of belt on its own hook in a nice organized fashion.
A couple vice stations.
Metal and wood cutting bandsaws.
Small but precise table saw
Small joiner
A good mill. I'm not up on the specifics of milling, but if we're in fantasy land here I'll go with a nice industrial CNC machine with all the automation and self calibration and alignment I can get. I want the machine to tell me when I'm messing up as much as possible. I'm a computer guy, so I'm more comfortable sitting down and programming a sequence for a part than I imagine I would be doing it by hand. I can see the potential use for a small but well made manual though, for a simple part I only intend to make once.
A good drill press for 3/16" and larger holes. Another well suited to smaller holes. Ideally though it would be a single drill press with digital speed control and a chuck that goes from pin holes to large bore stuff with no loss of precision. Within reason I expect I'd start using the mill for a lot of what I now use the drill press for.
A tapping station, I hate doing this by hand.
Salt tanks for heat treating, along with the other required equipment.
Since we're going "ideal" I'll add a decent forging station. Since we're in fantasy land can we include a clone of Sam who helps out with all the blacksmithing work, never needs fed or paid, and cleans the shop when I'm not there? We can clone him a companion of his choice too, since we're not worried about practicalities here.
The last thing I'd want that's specific to the shop is a good air filter/vac system setup with ports at each tool. I don't need a huge one, I'm ok with a unit that needs me to open and close each port to maximize suction. Of course, if we're going crazy and money's really no object at all, and neither is space, sure, go for the huge one that can run them all at once.
In another room, with either a double door or rotating door access from the dirty area, a finishing area with storage for handle materials, finishes, glues... Plenty of counter space, lots of clamps, a little snack prep area too.
I'd probably put a computer in here as well. Run speakers there and in the dirty area to play music off the computer, with a remote.
A couple presses for kydex work along with more storage for kydex and other sheath materials.
A work area for leather along with another clone, I'm not sure who for leather work, but I'd figure it out.
For both areas, tons of light but on multiple switches and dimmers so it's fully adjustable, including natural light. Good heating and cooling, insulated both for temp and sound so I can work whenever I want without disturbing anyone.
I'm sure I'll come up with more ideas but that's the gist of it. Can we add an indoor 75' shooting range able to handle up to 50bmg?
Fully insured, no property taxes, full fire prevention/mitigation system....
ETA: Thanks for reminding me. The sanding station and handle work area come with Nick Wheeler clones.
My new shop is 36'X48' and I love it, but right at this point, I only have about 700 sq ft of it set up with tools. I need to move a wall on the other side, and build another one as well. Even with that in mind, it's crazy to go from my old shop where everything was within about 10 paces of everything else, to the new space where the grinders are 35' away from the finish work bench. I still haven't gotten used to it. (but I'm glad to "put up" with this newfound issue 
