Another lefty here. I have the LH PM2 and LH Military models. I tried using a RH PM2 and couldn't get used to it. In general, I can use RH liner or frame locks. The thing that bugs me the most is occluded Spyderholes/thumb studs to where I can't easily open the knife. I complained about it on Spyderco's forum a while back when most of their new lineup was right handed compression locks and occluded Spyderholes. I've saved a lot of money by not purchasing knives that are not only not friendly to left handed people, they really just aren't usable.
I recently bought a Spyderco Advocate since it was discontinued and on sale. The Spyderhole is usable with my left hand but it took some practice to use it easily. I saw a youtube reviewer complaining about opening it with his right hand and I had to laugh. It's fully accessible and even has a cutout in the scale to make it easier for right hand opening. In contrast, my Manix 2 is fully ambidextrous and much easier to use. The Advocate works fine with the flipper, and I can easily use a right handed frame lock, so I just won't use the Spyderhole much.
I recently bought a Spyderco Advocate since it was discontinued and on sale. The Spyderhole is usable with my left hand but it took some practice to use it easily. I saw a youtube reviewer complaining about opening it with his right hand and I had to laugh. It's fully accessible and even has a cutout in the scale to make it easier for right hand opening. In contrast, my Manix 2 is fully ambidextrous and much easier to use. The Advocate works fine with the flipper, and I can easily use a right handed frame lock, so I just won't use the Spyderhole much.