In those pictures, is the guard on the tang, or just sitting above it for mock-up? I ask because the guard looks pretty huge for the overall knife, and particularly tall above the spine. If either side of the guard is longer than the other, you usually want it to be the knuckle side for visual balance.
It appears to me that you have put the tang slot right in the middle of the guard. Since your blade tang is not centered in the ricasso, but rather is above the centerline, the guard as built will look "high" on the blade. Often you'll want to slot your guard a little higher than center for a good flow to the knife.
I like the profile you are going with on the guard, though. I also think you are right to go with the more centered frame. The only thing I'd watch there- the line of the top of the frame, and hence your handle, looks like it will be higher than the line of your spine at the ricasso. I can't see how much really- it might be fine, but I've seen many knives that looked clunky because of this. It looks nice if the front of your handle is about the same size and in line with your ricasso, or if there is a difference in width, that it be on the knuckle side.
Don't think I'm trying to pick your knife apart, or that I have only bad, annoying things to say- I think you are doing a good job and this has the potential to be the best work you've done yet.