For a true framelock, I tend to stick to 0.125" to 0.150".
It seems a good compromise between handle thickness, rigidity in the load-bearing portion of the slab (i.e. no handle scales to hold things in place), and the lockbar relief.
0.100" and under (0.093", 0.080") is thinner, but I feel it makes for a too-thin handle. In this thickness I actually like a scale or a half-scale on the lock side.
Basically, my feeling is that the extra thickness is just giving you bend-resistance on the lockbar itself, since the relief is often cut down to below 0.050" anyhow.
-j