i dont just think opening and closing them effects liner locks or frame locks to any big degree, inertia opening the liner locks or to a lesser degree waving liner locks a whole whole lot probably does get them out of adjustment quicker, i dont think it effects frame locks at all FWIW, oh maybe if ya were obssesive/compulsive about it and did it a hundred times a day for say 3 yrs or something, but i dont think the average person will hurt a frame lock.
and then again a bud has a emerson commander '99 model he edc's at work(he's a framing contractor FWIW), and has for the last 8 or 9 yrs, & he cuts EVERYTHING with that knife, waves it no telling how many times a day, inertia opens it quite a bit, and the liner is maybe a HAIR past 1/3 of the way, really right were it should be, and locks up fine. i get to examine the knife every month or 2, and have since it was new, he cant sharpen it so he always gets me to do it when it gets dull, and it is as scuffed/scratched/stained as much as any EKI i have ever seen, but lockup on it is 100%.
go figure, huh?