Well, since some municipalities are now targeting pocket clips as some indicator of the murderous masses, I see some other way of carrying a knife for easy, convenient access developing. Similarly, a progeny of the current assisted openers will probably be developed. to circumvent any laws in that area. I'm sure many plainly stupid policies/laws will drive future knife design.
Conversely, I can see more "combat" slip-joints in the future. (Boy, that is a bad turn of phrase, "Combat Slipjoint") The UKPK seems to be doing well and offers about 90% of the performance of its locked blade brothers (depends upon how much you value a locking blade - for some unsafe things I do, a lockblade is neccessary). Not too many bolted together slip joints out there yet.
Not sure on the steel front. There is a limit as to what is a useful hardness for knives (many bemoan the "difficulties" high hardness steels already cause). Perhaps a better sharpening material will be made for these wonder metals.
Don't see handheld cutting lazers and other such "Star Wars" stuff. Just what I need, a battery dead cutting implement. Further, as with knives, I don't see such things ever being legal to carry (what would CSI do for evidence?).