Stay away from things like Glaser Safety Slugs. They may or may not work; there's a good possibility they won't penetrate far enough to incapacitate a bad guy.
This is just my opinion, so take it for what it's worth: I vote for Winchester Ranger SXT ammo (which is almost identical to the discontinued Black Talons) or Federal Hydra-Shok. The best advice is that if you want a handgun for home defense, have the best handgun/caliber combination you can shoot comfortably, find the load that works best in it and practice
a lot - shot placement is everything.
I have an old Ruger Super Blackhawk .44 Magnum that's loaded with either Winchester Ranger SXT loads or Federal Hydra-Shoks. Many folks consider a Ruger Super Blackhawk a little large for home defense, but I can shoot mine at least as well as I can shoot a rifle, and my wife & son can handle it too.
A friend here is a LEO in Northern California, and his advice for home defense is a shotgun: preferably a 12 gauge; the huge diversity of load options allows you to handle just about any situation. Even an up-close shot with bird shot in a bad guy's center-of-mass will settle things pretty quickly, and you have quick follow-up shots ready. If 12 gauge is too much, then a smaller gauge (20 gauge or even .410) will work too.
Also, for records and all, some modern pellet rifles have taken large animals in Africa. All about shot placement.
Years ago I read an article about African calibers, and the writer (Capstick?) knew of an old farmer in one of the African countries who had a problem with an elephant coming into his little garden and ripping up the plants and presumably eating everything. One day the old farmer goes out with an antique .22 rimfire, with the intention of "scaring off" the beast, and he shot randomly at it. He somehow hit it in the ear, and the bullet managed to get far enough into the elephant's head that it died, right there on the spot. The problem was that this was either a full-grown elephant or close to it, and it collapsed down into a sitting position, and the old farmer couldn't move it. His family finally got the army to come drag the elephant off his property, and no one would believe he'd only shot it with a .22, until they cut it up and checked it out themselves.
Shot placement really is everything.
~Chris