On one of my 21s, a large micarta lefty, the blade was slightly off- center, and it bugged me like crazy. I needed to fix it, and did not want to send it back. I had just gotten it, and it was a Sebenza! Not cheap.
I tried everything, even looked to swap the washers from one side to the other (like I had to do with some, including my Gold Class Benchmade 940-121 to get it to center perfectly) but one cannot do that with a 21. The washers are different diameters.
I ended up reversing the screws that hold the scales together, in different combinations, as all three are the same size, including the pivot. Spent over an hour trying different combinations until I got it to be perfect. My 21 Insingo is as stock, all oriented the same direction, the deeper side facing toward the presentation side. Same with my 25, which I never have had to touch. Thankfully!
But on my large 21 micarta, the pivot and the screw set right above it are deep on the presentation side, and shallow on the one near the lanyard. It really should make no difference, as they are supposed to be the same length when tightened, but honestly it did. I think I had two the opposite way as from the factory and it still was not right, so I turned that one around and it worked. I tried every combination possible, believe me. This screw set in that hole, deep side left, then right, all deep on left, all deep on right, etc.
One thing is I at times had all of them loose, then tightened them up slightly from one end to the other slightly, then repeated, more each time. Kind of like you do with automobile lug nuts, you criss-cross, but the knife was different because I BARELY put more tension on each one at a time until it was centered and they were all tight. I then carefully removed the pivot male screw, put purple locktite on it from my 25 box and carefully torqued it again until there was no blade play at all side-to-side and it was centered. And I left it alone for the rest of the day, as I was tired of working on it.
I have not had to touch it since then, and I've opened it 300-400 cycles by now. It has not moved since the day I did all that, sometime in October.
When I do take it apart to clean it in the future, I will be very careful to set the screw sets in the orientation they were removed in, and will use an inch-lb torque wrench to see what torque they are at right now when I remove them. I'll start at a very light setting and keep moving up until the screw moves, then write it down. But if that doesn't work in practice as in theory, no worries. I will be able to repeat it, as it is that way right now.
I used to roadrace motorcycles and this is pretty much standard stuff. You have to tweak things a lot (like suspension settings) and it's so much that you'd better write it down or you can never go back to what worked before you adjusted your way out of something that worked better than what you ended up with later by trying different adjustments.
Yes, you should not have to go through this with a knife that costs as much as many guns do. But they are production items, and you'll have that. I would exhaust everything you can at home before sending it in, because you might not see it back for six weeks.
But if you still do not like it, I'd send it back to CRK. They should be able to correct it, and if it comes back not to your liking you can sell it with no guilt, as you're not screwing you anybody. It came through CRK quality control a second time and someone else may not be as persnickety as you and I am. I am a perfectionist to the point I will look at, say, every hat on a shelf before I choose the best one, bill straightest, logo the most centered, etc. That's just how I am.