Start with getting the front end symmetrical. That shows worse than most other errors. Before you attach the scales, tape them together with the rivets through the holes ( not on the knife tang). Sand and shape the front so it is even and as symmetrical as you can get. Sand to at least 400 grit and buff if you do that. This assures the front is symmetrical, and avoids ruining the blade in handle finishing.
Attach the scales on the knife with epoxy and rivets, let cure 24 hours, and tape off the blade with a couple layers of blue or green painters tape.
Grind the handle profile down to the tang. At this point the silhouette of the knife should look like what you want.
Flatten and thin the scales to make them even looking down from the top/bottom.
Taper the scales a little so the bottom is a bit less wide than the top. ( This varies depending on handle shape and style, but on most knives this gives a better feel in the hand. The final cross section is usually a slightly egg shaped oval)
Knock off the corners of the handle all the way around at 45°.
Start rounding the handle from top to bottom and then from bottom to top. Try for a smooth curve with no angles.
Shape any features like finger grooves, hour-glass shape/coke-bottle/palm swells after the sides are evenly rounded.
Adjust the taper of butt towards the end as the very last thing.
Done in these steps, it is hard not to be symmetrical.