Let me jump in with the voice of an overweight mid 50's guy with a wide foot, high arches, high instep, and has spent some time on WNC trails and MUCH time on pavement (former senior firearms instructor for mid-sized agency). Some boots I can't even get my feet in if the tongue is sewn too far up the boot or too tightly at the instep-and I mean some that are HUGELY favored...
So far Merrells (discontinued GeoMorph Blaze, but close to cousin to a Moab) are the most comfortable I've ever hiked in. Once a fellow firearms instructor (hearing me rave on and on about how comfortable they were) once said "Okay we get it! You're saying they are like walking on two clouds of (*insert slang word for female genitalia*)!!! Right behind this for me is the Danner 600 (as someone mentioned early in the thread.) I have three pair-one relegated to mowing grass but one for hiking and one for casual wear. Danner hit a homerun with these.
I just bought a pair of Zamberlains-and I *think* I'm going to like them, but they are heavier than I prefer and stiff. I will wear them casually (to work and out to town) for at least a year before even considering them for hiking.
Also, I run a similar insole in everything-I like Superfeet Green and SOLE, but the Copper Fit ($9 at CVS!) seem to do as good as they do for 1/3 to 1/4 of the price.