Everything else being equal, whether the lock is made of titanium or stainless steel, frame locks tend to be thicker.
Thicker material takes longer to wear down than thinner, everything else again being equal.
Therefore, for the same amount of use, liner locks should wear down long before frame locks.
FWIW, unless you use your knives really, really hard, a good quality knife such as the Benchmade Gravitator should last you for a lifetime of use without any noticeable wear on the liner lock.