I am new to Spyderco's just received my Endura from Knife Works and love it. It is my heavy duty outdoor folder. I have big hands and have found the safest way for me to open one handed is using my index finger in the hole and my thumb, pushing on the spine to lock it. It is one-hand but not very fast. The hole is too small for much of my thumb to go in. I say safest because my hand looks like I got in a fight with cat. Those serrations will reach out and get you when you slip up.
I've thought about wrapping the top of the hole with cord or applying "plasti-dip" to increase grip in that area for the pad of my thumb.
I've thought about wrapping the top of the hole with cord or applying "plasti-dip" to increase grip in that area for the pad of my thumb.