I've tried quite a few different ways throughout the years. My latest and current setup is a KME with their standard Gold Series Diamond stones. I can get absolutely just insane edges with it. My go to method is to profile the edge on the KME the first time I sharpen a new knife. I like to reprofile everything to about 15-17 degrees, however if the factory bevel isn't too obtuse I might stick with the factory angle just because if I reprofiled all my knives to 15 degrees, it'd just take up too much of my free time. But no matter the angle, even if I keep the factory angle, I still need to profile every single edge because no edge comes to me already perfectly even unless I bought the knife from a master sharpener (I'm not a master, but can hold my own well enough). I usually progress up to 600 grit on most knives, but go to 1500 on some, and then I'll strop. Then, I'll use a combination of my Sharpmaker and strop to maintain that edge until it really needs a new profiling and I'll use the KME again. I've also been doing a bit of freehand here and there.
Edit: I got going and forgot the main question... I like all my knives to be able to shave my arm or leg hair. Sometimes I'll stretch the edge out a bit longer than I like though just because I can get lazy.