I think that Ergonomics is pretty important, but need to be closely related to the weight, design of the knife, skill and strength of the operator and expected circumstance of use. . In a professional environment, the proliferation of lightweight stab proof body armour makes long pointy things a second option in my view. The Fairbairn Sykes was designed in an era where body protection was not in common use. In a modern scenario, the targets are relatively small exposed areas of the body with vulnerabilities close to the surface, a knife only needs to be a few inches to reach those. If there is an assumption that artillery, hand grenades and bullets have failed, the design characteristics I would be considering are; Security of weapon in holder, ease of access, small enough to be used in close combat or restricted space, sharp enough and tough enough to damage target areas.